Roberto Di Matteo has resigned as manager of German side Schalke after seven and a half months in charge.
Former Chelsea boss Di Matteo, 44, took over in October 2014 and steered the Bundesliga side from 11th to third.
But defeat by strugglers Hamburg on Saturday left Schalke with two wins from 10 games to miss out on a Champions League place.
Schalke ended the season sixth meaning they will compete in next season's Europa League.
The Italian led Chelsea to the 2012 Champions League title but was replaced by Spaniard Rafael Benitez after eight months.
Di Matteo said he resigned because of a difference of opinion over plans for next season following a meeting with the club's director of sport Horst Heldt.
"I offered a plan for a possible successful future and what the conditions for that would need to be," said Di Matteo, who had two years left in his contract.
"It became clear that the club had a different emphasis. This is why I decided to resign from my position as head coach."
In a feat that calls to mind the memory-tweaking technology in the film "Eternal Sunshine of the Spotless Mind," a team of researchers restored "lost memories" in the brains of mice. The mice in the study were given a drug that prevented them from consolidating a fearful memory. But when neurons involved in encoding the memory were stimulated with pulses of light, the animals were able to retrieve the forgotten recollection. In some forms of amnesia, past memories may not be erased, but may just be inaccessible for recall, said Susumu Tonegawa, director of the RIKEN Brain Science Institute in Japan and co-author of the study, said in a statement. If the findings are confirmed in humans, the knowledge could benefit people who suffer from retrograde amnesia, an inability to recall memories that were made before the amnesia, which is common in traumatic brain injury, Alzheimer's disease and other brain disorders. Scientists have long debated whether retrograde ...
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